Your cancer’s mutations
Cancer occurs due to changes in DNA and/or RNA called mutations that affect the way your cells work and grow.4,5
Each person’s cancer is unique because DNA mutations between cancers differ in type and number.6,7
Even if you have the same type of cancer as someone else, your DNA mutations may differ to theirs, and you may need different treatment.6–8
Your care team might suggest testing your cancer to find out what mutations you have in your DNA and/or RNA.
If certain mutations are found in your cancer cells your doctor may be able to give you a more precise treatment based on this finding. There might be cases where either no relevant mutation is found or no targeted treatment option is available for the mutation that has been identified. This is also valuable information, supporting further treatment planning.6–11
Precision medicine increases the likelihood you will find a targeted therapy, which may improve your chance of responding well or could mean that you experience fewer side effects.3
What is comprehensive genomic profiling?
Genomic testing encompasses single biomarker testing, hotspot testing and comprehensive genomic profiling. They all test your cancer sample for mutations but work in different ways.
How does comprehensive genomic profiling help?
Foundation Medicine offers a high-quality portfolio of comprehensive genomic profiling services that may help you and your doctor better understand your treatment options.1,14–17
There are different tests available for patients with different types of cancer.
FoundationOne®CDx, FoundationOne®Liquid CDx and FoundationOne®Heme search for multiple mutations in your cancer sample to increase your chances of finding a more precise treatment and help personalise your cancer treatment
plan.1,2,13–17,22–32 FoundationOne CDx and FoundationOne Liquid CDx are for patients with all types of solid tumours, e.g. lung, prostate or breast cancer.14,15 FoundationOne Heme is for patients with sarcoma and blood cancers such as leukaemia.17
Your care team will receive a comprehensive report which will include the details on your tumour profile and may identify therapies and clinical trials for you to discuss together.6–11,33